Amber Heard lost her "battle" to cancel the court decision for ex-husband Johnny Depp.
Heard's team claimed there were flaws in the trial process, as one juror was replaced by her son.
Judge Penney Azcarate said there was "no evidence of fraud or wrongdoing". Azcarate said the juror "met the legal requirements" and had been questioned and approved by both sides beforehand.
The six-week media-broadcast trial was one of the most high-profile cases in years. Depp sued his ex-partner for defamation over a 2018 article she wrote for the Washington Post in which she described herself as a survivor of domestic abuse. He was awarded $10.35 million in damages.
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