Modern regenerative dermatology no longer focuses solely on correcting the visible signs of aging, but on preventing and supporting the long-term freshness of the skin. Every skin has specific needs, which vary depending on age and hormonal phases such as perimenopause or menopause.
According to dermatologists, the modern approach aims to activate the skin's natural regeneration mechanisms. Over time, the skin loses not only volume, but also dermal density, elasticity and structural integrity. For this reason, new treatments are designed to act deeply and biologically.
Below are some of the most advanced and effective treatments in contemporary aesthetic dermatology:
Controlled surface rejuvenation – Fractional CO? laser
What it is: Fractional ablative laser used for skin regeneration and improvement of its texture.
How it works: Creates microscopic columns of thermal damage (microthermal zones) in the epidermis and dermis, stimulating neocollagenogenesis and dermal remodeling.
Benefits: Reduces wrinkles, improves skin texture and pigment, increases dermal density and improves its overall quality with progressive results.
Radio Frequency (RF) Microneedling
What it is: Combined treatment with microneedling and radiofrequency energy for deep dermal stimulation.
How it works: Microneedles penetrate the dermis and transmit controlled thermal energy, activating fibroblasts and stimulating the synthesis of type I and III collagen and elastin.
Benefits: Improves skin laxity, texture and density, and provides natural results.
Cellular Regeneration – Microneedling with Exosomes
What it is: Advanced therapy that combines microneedling with topical application of exosomes (extracellular vesicles with biological signals).
How it works : Microneedling increases and activates repair processes, while exosomes transport factors and signals that promote cellular regeneration.
Benefits: Increases collagen production, accelerates recovery, improves skin tone and radiance. Ideal for hormonally stressed skin.
Cellular biostimulation – Polynucleotides (PN)
What they are: Bioactive polynucleotides (DNA/RNA fragments) with high biocompatibility, used as regenerative injections.
How they work : They improve fibroblast activity, stimulate angiogenesis, and increase hydration of the extracellular matrix.
Benefits: Increases skin elasticity and vitality without altering its natural features. Ideal for prevention and for thin or damaged skin.
Long-term collagen stimulation – Poly-L-Lactic Acid (PLLA) What is it:
Injectable biostimulant with long-lasting effect.
How it works: Gradually stimulates neocollagenogenesis, without an immediate volumizing effect.
Benefits: Improves dermal structure, skin firmness and elasticity progressively and naturally.
Deep Biostimulation – Calcium Hydroxyapatite (CaHA)
What it is: Biocompatible injectable material with biostimulating and structural effects.
How it works: Creates a "scaffold" (support network) in the dermis that stimulates fibroblasts and collagen production.
Benefits: Increases skin density, improves elasticity without adding excess volume. Also suitable for patients experiencing weight loss (e.g. during GLP-1 receptor agonist therapies).
